研究者画像

大木 研一

主任研究者

発生/発達研究

東京大学大学院医学系研究科 機能生物学専攻統合生理学 教授

単一ニューロンin vivoイメージングを用いた視覚野における情報処理能の解析

研究概要

I am interested in visual neuroscience and functional brain mapping. In 2005, I developed a method of single-cell resolution functional mapping with two-photon calcium imaging, and was able to measure the orientation selectivity of hundreds of neurons in visual cortex revealing the functional architecture of visual cortex between rodents and higher mammals (Ohki et al., 2005, Nature). In 2006, using this method, I solved a long-standing problem in visual neuroscience - the micro-architecture of pinwheel centers at the single-cell level (Ohki et al., 2006). In 2012, I found that neurons derived from the same neural stem cells tend to acquire similar orientation selectivity in the adult mouse visual cortex (Ohtsuki et al., 2012) and later that neuronal activity is not required for the initial formation of orientation selectivity, but required for the later reorganization (Hagihara et al., 2015). Our lab continue to study the interplay between innate circuits determined by the developmental programs, and neuronal activity in determining the functions of neurons in the cerebral cortex.

研究テーマ画像

主要論文

Matsui T, Murakami T, Ohki K. Transient neuronal coactivations embedded in globally propagating waves underlie resting-state functional connectivity. Proc Natl Acad Sci U S A. 113:6556-61 (2016).

Kondo S, Ohki K. Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex. Nat Neurosci.,19: 316-9 (2016).

Hagihara KM, Murakami T, Yoshida T, Tagawa Y, Ohki K. Neuronal activity is not required for the initial formation and maturation of visual selectivity. Nat Neurosci.,18: 1780-8 (2015).

Kawashima T, Kitamura K, Suzuki K, Nonaka M, Kamijo S, Takemoto-Kimura S, Kano M, Okuno H, Ohki K, Bito H. Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE. Nat Methods. 10: 889-895 (2013).

Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed MH, Lois C, Ohki K Similarity of visual selectivity among clonally related neurons in visual cortex. Neuron. 75: 65-72 (2012).

T. Mrsic-Flogel, S. B. Hofer, K. Ohki, R. C. Reid, T. Bonhoeffer, M. Hubener. Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. Neuron. Vol. 54:961-72 (2007).

Ohki K, Chung S, Kara P, Hubener M, Bonhoeffer T, Reid RC. Highly ordered arrangement of single neurons in orientation pinwheels. Nature 442: 925-928 (2006).

Ohki K, Chung S, Ch'ng YH, Kara P, Reid. RC Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. Nature 433: 597-603 (2005).

Ohbayashi M, Ohki K, Miyashita Y. Conversion of working memory to motor sequence in the monkey premotor cortex. Science 301: 233-6 (2003).

H. Kikyo, K. Ohki, Y. Miyashita. Neural correlates for feeling-of-knowing: an fMRI parametric analysis. Neuron 36: 177-86 (2002).

略歴

1996年    東京大学医学部医学科卒業・医師免許取得
2000年    東京大学医学系研究科修了・博士号(医学)取得
2000年-2002年    東京大学医学系研究科・統合生理学・助手
2002年-2008年    ハーバード大学医学部・神経生物学・リサーチフェロー
2008年-2010年    ハーバード大学医学部・神経生物学・インストラクター
2010年-2016年    九州大学大学院医学研究院・分子生理学・教授
2016年-    東京大学医学部医学系研究科・統合生理学・教授