Associate Professor, Graduate School of Medicine (Continues as IRCN Associate Professor (concurrent appointment))
Neuroimaging of Psychiatric Disorders and Adolescent Development
Research
Functional magnetic resonance imaging (fMRI) facilitates the quantitative assessment of brain structure and function in vivo. Our laboratory conducts human brain MRI studies in healthy adolescents and in patients with psychiatric disorders to understand the mechanisms linking them. Recently, we have reported a new brain-based classification related to cognitive and social functions, using a large-scale data set from a multi-site consortium. Current research is directed toward elucidating psychiatric disorders by revealing their neurobiological substrates and developing biomarkers for clinical applications. In addition, given the importance of international collaboration among MRI researchers, of connecting human and animal research, and of applying machine learning and AI techniques..., we collaborate extensively with multi-disciplinary researchers.
Publications
Okada N, Yahata N, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Edden RAE, Sawa A, Kasai K. Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization. Mol Psychiatry. 2024 Apr;29(4):939-950. doi: 10.1038/s41380-023-02382-8.
Okada N, Fukunaga M, Miura K, Nemoto K, Matsumoto J, Hashimoto N, Kiyota M, Morita K, Koshiyama D, Ohi K, Takahashi T, Koeda M, Yamamori H, Fujimoto M, Yasuda Y, Hasegawa N, Narita H, Yokoyama S, Mishima R, Kawashima T, Kobayashi Y, Sasabayashi D, Harada K, Yamamoto M, Hirano Y, Itahashi T, Nakataki M, Hashimoto RI, Tha KK, Koike S, Matsubara T, Okada G, van Erp TGM, Jahanshad N, Yoshimura R, Abe O, Onitsuka T, Watanabe Y, Matsuo K, Yamasue H, Okamoto Y, Suzuki M, Turner JA, Thompson PM, Ozaki N, Kasai K, Hashimoto R. Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification. Mol Psychiatry. 2023 Dec;28(12):5206-5216. doi: 10.1038/s41380-023-02141-9.
Okada N, Yamamoto Y, Yahata N, Morita S, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Yokoyama C, Kasai K. Birth order and prosociality in the early adolescent brain. Sci Rep. 2021 Nov 8;11(1):21806. doi: 10.1038/s41598-021-01146-0.
Okada N, Yahata N, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Kasai K. Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences. Transl Psychiatry. 2018 Nov 28;8(1):254. doi: 10.1038/s41398-018-0312-6.
Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, Ohi K, Yasuda Y, Fujimoto M, Watanabe Y, Yahata N, Nemoto K, Hibar DP, van Erp TG, Fujino H, Isobe M, Isomura S, Natsubori T, Narita H, Hashimoto N, Miyata J, Koike S, Takahashi T, Yamasue H, Matsuo K, Onitsuka T, Iidaka T, Kawasaki Y, Yoshimura R, Watanabe Y, Suzuki M, Turner JA, Takeda M, Thompson PM, Ozaki N, Kasai K, Hashimoto R. Abnormal asymmetries in subcortical brain volume in schizophrenia. Mol Psychiatry. 2016 Oct;21(10):1460-6. doi: 10.1038/mp.2015.209.
Biography
I obtained an M.D. degree from the Faculty of Medicine of the University of Tokyo in 2004. After a junior residency, I started psychiatry training at the University of Tokyo Hospital in 2006 and then worked as a psychiatrist at Tokyo Metropolitan Matsuzawa Hospital from 2007 to 2012. I became an Assistant Professor at the University of Tokyo Hospital in 2012 and concurrently entered the Graduate School of Medicine of the University of Tokyo earning a Ph.D. degree in 2017, before joining IRCN in 2019 where I manage the human fMRI scanner facility. At the same time, I am continuing research on the neuroimaging of psychiatric disorders and adolescent development.
