研究者画像

Naohiro Okada, M.D., Ph.D.

Human fMRI Core Manager

Project Associate Professor

Neuroimaging of Psychiatric Disorders and Adolescent Development

Research

Functional magnetic resonance neuroimaging (fMRI) facilitates the quantitative assessment of brain structure and function in vivo. Our laboratory conducts human brain MRI studies in healthy human adolescent development and patients with psychiatric diseases to understand the mechanisms linking them. Recently, we have reported alterations of subcortical regional volumes in patients with schizophrenia using a large-scale data set from a multi-site consortium. Current research is directed to elucidate psychiatric disorders by revealing their neurobiological substrates and developing biomarkers for clinical applications. In addition, given the importance for MRI researchers to collaborate internationally, to connect human and animal research, and to apply machine learning and artificial intelligence techniques, we collaborate extensively with multi-disciplinary researchers.

研究テーマ画像

Publications

Okada N, Ando S, Sanada M, Hirata-Mogi S, Iijima Y, Sugiyama H, Shirakawa T, Yamagishi M, Kanehara A, Morita M, Yagi T, Hayashi N, Koshiyama D, Morita K, Sawada K, Ikegame T, Sugimoto N, Toriyama R, Masaoka M, Fujikawa S, Kanata S, Tada M, Kirihara K, Yahata N, Araki T, Jinde S, Kano Y, Koike S, Endo K, Yamasaki S, Nishida A, Hiraiwa-Hasegawa M, Bundo M, Iwamoto K, Tanaka SC, Kasai K. The population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): a cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development. Psychiatry Clin Neurosci [Epub ahead of print]

Okada N, Yahata N, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Edden RAE, Barker PB, Sawa A, Kasai K. Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence. Sci Rep 2019;9:732.

Okada N, Yahata N, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Kasai K. Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences. Transl Psychiatry 2018;8:254.

Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, Ohi K, Yasuda Y, Fujimoto M, Watanabe Y, Yahata N, Nemoto K, Hibar D, van Erp T, Fujino H, Isobe M, Isomura S, Natsubori N, Narita H, Hashimoto N, Miyata J, Koike S, Takahashi T, Yamasue H, Matsuo K, Onitsuka T, Iidaka T, Kawasaki Y, Yoshimura R, Watanabe Y, Suzuki M, Turner J, Takeda M, Thompson P, Ozaki N, Kasai K, Hashimoto R; COCORO: Abnormal asymmetries in subcortical brain volume in schizophrenia. Mol Psychiatry 2016;21:1467-1476.

Okada N, Takahashi K, Nishimura Y, Koike S, Ishii-Takahashi A, Sakakibara E, Satomura Y, Kinoshita A, Takizawa R, Kawasaki S, Nakakita M, Ohtani T, Okazaki Y, Kasai K: Characterizing prefrontal cortical activity during inhibition task in methamphetamine-associated psychosis versus schizophrenia: A multi-channel near-infrared spectroscopy study. Addict Biol 2016;21:489-503.

Biography

I obtained an M.D. degree from the Faculty of Medicine of the University of Tokyo in 2004. After a junior residency, I started psychiatry training at the University of Tokyo Hospital in 2006 and then worked as a psychiatrist at Tokyo Metropolitan Matsuzawa Hospital from 2007 to 2012. I became an Assistant Professor at the University of Tokyo Hospital in 2012 and concurrently entered the Graduate School of Medicine of the University of Tokyo earning a Ph.D. degree in 2017, before joining IRCN in 2019 where I manage the human fMRI scanner facility. At the same time, I am continuing research on the neuroimaging of psychiatric disorders and adolescent development.