{"id":7442,"date":"2018-06-04T12:53:30","date_gmt":"2018-06-04T03:53:30","guid":{"rendered":"http:\/\/ircn.jp\/?p=7442"},"modified":"2019-04-15T15:24:49","modified_gmt":"2019-04-15T06:24:49","slug":"early-life-seizures-disrupt-critical-period-plasticity","status":"publish","type":"post","link":"https:\/\/ircn.jp\/en\/pressrelease\/early-life-seizures-disrupt-critical-period-plasticity","title":{"rendered":"Early-Life Seizures Disrupt Critical Period Plasticity"},"content":{"rendered":"<p><strong>In Brief:<\/strong><br \/>\nEarly-life seizures are often associated with intellectual disability and\/or autism. Sun et al. show that seizures prematurely unsilence synapses to disrupt tonotopic plasticity in auditory cortex, revealing a mechanism for the relationship between seizures and later cognitive impairment.<\/p>\n<p><strong>Highlights:<\/strong><\/p>\n<ul>\n<li>Early-life seizures disrupt a critical period for tonotopic map plasticity in A1<\/li>\n<li>Maturational decrease in NMDA-only silent synapses characterizes this CP<\/li>\n<li>Seizures accelerate synapse unsilencing by AMPA receptor insertion<\/li>\n<li>An AMPAR antagonist prevents synapse unsilencing and rescues CP plasticity<\/li>\n<\/ul>\n<p><strong>Graphical Abstract:<\/strong><br \/>\n<img decoding=\"async\" loading=\"lazy\" class=\"alignnone wp-image-7446 size-medium\" src=\"http:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract-300x300.jpg 300w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract-150x150.jpg 150w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract-768x766.jpg 768w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract-1024x1021.jpg 1024w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract-55x55.jpg 55w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract-947x945.jpg 947w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract-624x622.jpg 624w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/Graphical-Abstract.jpg 1216w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p><strong>Summary:<\/strong><br \/>\nHeightened neural excitability in infancy and child-hood results in increased susceptibility to seizures. Such early-life seizures are associated with language deficits and autism that can result from aberrant development of the auditory cortex. Here, we show that early-life seizures disrupt a critical period (CP) for tonotopic map plasticity in primary auditory cor-tex (A1). We show that this CP is characterized by a prevalence of \u2018\u2018silent,\u2019\u2019 NMDA-receptor (NMDAR)-only, glutamate receptor synapses in auditory cortex that become \u2018\u2018unsilenced\u2019\u2019 due to activity-dependent AMPA receptor (AMPAR) insertion. Induction of sei-zures prior to this CP occludes tonotopic map plasticity by prematurely unsilencing NMDAR-only synapses. Further, brief treatment with the AMPAR antagonist NBQX following seizures, prior to the CP, prevents synapse unsilencing and permits sub-sequent A1 plasticity. These findings reveal that early-life seizures modify CP regulators and suggest that therapeutic targets for early post-seizure treat-ment can rescue CP plasticity.<\/p>\n<p><strong>Journal Articles:<\/strong><br \/>\nCell Reports 23, May 29, 2018<br \/>\n<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(18)30706-X\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(18)30706-X<\/a><\/div>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"alignright size-medium wp-image-7486\" src=\"http:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/0fccc2ae400c120720e6c6af65af9a4d-300x58.png\" alt=\"\" width=\"300\" height=\"58\" srcset=\"https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/0fccc2ae400c120720e6c6af65af9a4d-300x58.png 300w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/0fccc2ae400c120720e6c6af65af9a4d-285x55.png 285w, https:\/\/ircn.jp\/wp-content\/uploads\/2018\/06\/0fccc2ae400c120720e6c6af65af9a4d.png 519w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><br \/>\n<\/p>","protected":false},"excerpt":{"rendered":"In Brief: Early-life seizures are often associated with intellectual disability and\/or autism. Sun et al. show that seizures prematurely unsilence synapses to disrupt tonotopic plasticity in auditory  [&hellip;]","protected":false},"author":5,"featured_media":7446,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_links_to":"","_links_to_target":""},"categories":[185],"tags":[],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.9 - aioseo.com -->\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"IRCN \u4e8b\u52d9\u5c40\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/ircn.jp\/en\/pressrelease\/early-life-seizures-disrupt-critical-period-plasticity\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.9\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"| The University of Tokyo International Research Center for Neurointelligence\" \/>\n\t\t<meta property=\"og:type\" 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